Metabolic modulation and multi-species interaction: Lactiplantibacillus plantarum’s impact on Streptococcus mutans-Candida albicans in a mucosal model
These findings demonstrate that <i>L. plantarum</i>, particularly when combined with GOS, exerts inhibitory effects on <i>S. mutans</i> and <i>C. albicans</i> in an oral mucosal model through metabolic and immunologic regulation. The results highlight the potential of synbiotic strategies (probiotics and prebiotics) for preventing and mitigating oral diseases involving the mucosal barrier and the pathogenesis of <i>S. mutans</i> and <i>C. albicans</i>.
Authors
- Lanxin Zhang (ORCID: https://orcid.org/0000-0002-6088-1538)
- Yan Wu (ORCID: https://orcid.org/0000-0002-6693-9657)
- Jin Xiao (ORCID: https://orcid.org/0000-0002-8776-2520)
- Nora Alomeir (ORCID: https://orcid.org/0000-0002-6893-3697)
- Ting Li (ORCID: https://orcid.org/0000-0002-0854-9124)
- Tongtong Wu (ORCID: https://orcid.org/0009-0000-2969-4972)
- Hiba Rashid Alyami
Institutions
- Harvard University (US)
- University of Rochester Medical Center (US)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-10-08
- DOI
- https://doi.org/10.3389/fcimb.2025.1652490
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 0.00