Unravelling key genes and molecular pathways in gastric inflammation-to-cancer transition through causal discovery: implications for early diagnosis and therapy

This study integrates graph neural networks and causal inference to identify critical genes involved in gastric inflammation-cancer progression, providing novel insights into the pathogenesis of gastric cancer and potential biomarkers for validation in future studies.

Authors

Jinjuan Li (ORCID: https://orcid.org/0000-0002-7033-321X)
Pengyun Liu (ORCID: https://orcid.org/0009-0001-2874-9131)
Shisan Bao (ORCID: https://orcid.org/0000-0002-6687-3846)
Zhen Ren (ORCID: https://orcid.org/0000-0002-2262-4880)
Xiaochen Li (ORCID: https://orcid.org/0000-0001-7833-8042)

Institutions

Gansu University of Traditional Chinese Medicine (CN)

Publication Details

Journal: SAGE Open Medicine
Published: 2025-10-01
DOI: https://doi.org/10.1177/20503121251380131
Citations: 1
Primary Topic: Helicobacter pylori-related gastroenterology studies
Type: article
Field-Weighted Citation Impact: 2.01

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article

Unravelling key genes and molecular pathways in gastric inflammation-to-cancer transition through causal discovery: implications for early diagnosis and therapy

Jinjuan Li, Pengyun Liu, Shisan Bao, Zhen Ren et al.

Oct 1, 2025

1 citations

SAGE Open Medicine

Helicobacter pylori-related gastroenterology studies

2.01

article

Unravelling key genes and molecular pathways in gastric inflammation-to-cancer transition through causal discovery: implications for early diagnosis and therapy

Jinjuan Li, Pengyun Liu, Shisan Bao, Zhen Ren, Xiaochen Li

October 1, 2025article en

1 citations

Abstract

This study integrates graph neural networks and causal inference to identify critical genes involved in gastric inflammation-cancer progression, providing novel insights into the pathogenesis of gastric cancer and potential biomarkers for validation in future studies.

SAGE Open MedicineVol. 13

Gansu University of Traditional Chinese Medicine (CN)

Openalex Percentile: Top 11%

Helicobacter pylori-related gastroenterology studies

2.01

DOI Open Access PDF OpenAlex

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Unravelling key genes and molecular pathways in gastric inflammation-to-cancer transition through causal discovery: implications for early diagnosis and therapy — Jinjuan Li, Pengyun Liu, et al. · SAGE Open Medicine (2025) | TGRS Research Map | TGRS