Clinical, Endoscopic and Histologic Differences in Gastric Mucosa Between Younger and Older Adults: An Observational Study on the Aging Stomach
Aging is associated with clinical, endoscopic and histologic changes in the gastric mucosa including CAG and metaplasia, independent of the presence of <i>H. pylori</i>. These findings may result from several aging-related pathophysiological processes and decades of cumulative gastric injury and support the hypothesis of an aging stomach phenotype, underscoring the need for an age-adjusted interpretation of gastric biopsies.
Authors
- Ivo Mendes (ORCID: https://orcid.org/0009-0003-1068-379X)
- Sara Pires (ORCID: https://orcid.org/0000-0003-2825-0928)
- Francisco Vara-Luiz (ORCID: https://orcid.org/0000-0002-3757-6172)
- Inês Costa Santos (ORCID: https://orcid.org/0000-0003-3332-8590)
- Gonçalo Nunes (ORCID: https://orcid.org/0000-0003-4920-9158)
- Jorge Fonseca (ORCID: https://orcid.org/0000-0001-6477-7028)
- Paulo Mascarenhas (ORCID: https://orcid.org/0000-0002-6584-1199)
- Carolina Palma
- Daniel Pinto (ORCID: https://orcid.org/0000-0002-8318-0945)
- Pedro Pinto-Marques (ORCID: https://orcid.org/0000-0001-9675-0751)
- Marta Patita (ORCID: https://orcid.org/0000-0003-1726-2528)
- Iancu Mocanu (ORCID: https://orcid.org/0000-0002-2676-3351)
- Ana Vieira (ORCID: https://orcid.org/0000-0002-8503-4765)
- Ana Elisa Teles
- Tânia Meira
Institutions
- Escola Superior de Saúde Egas Moniz (PT)
- Hospital Garcia de Orta (PT)
Publication Details
- Journal
- Medical Sciences
- Published
- 2025-10-08
- DOI
- https://doi.org/10.3390/medsci13040224
- Primary Topic
- Helicobacter pylori-related gastroenterology studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00