WGX50 attenuates radiation enteritis by targeting ferroptosis and redox homeostasis via EGFR
WGX50 demonstrates potent radioprotective effects by reducing oxidative stress, suppressing ferroptosis, and maintaining intestinal homeostasis, including goblet cell function and gut microbiota composition. These findings support WGX50's potential as a novel therapeutic agent for the prevention and treatment of radiation enteritis.
Authors
- Dong‐Qing Wei (ORCID: https://orcid.org/0000-0003-4200-7502)
- Guanjun Chen (ORCID: https://orcid.org/0000-0002-8629-2168)
- Zhijing Yin
- Yizhou Tan
- Yuxing Zhu (ORCID: https://orcid.org/0000-0002-8757-0676)
- Ke Cao (ORCID: https://orcid.org/0000-0001-5392-2306)
- Ganghua Zhang (ORCID: https://orcid.org/0000-0002-3603-6879)
- Yunqing Liu (ORCID: https://orcid.org/0000-0003-4794-3658)
- Jingyi Tang (ORCID: https://orcid.org/0000-0002-8754-5809)
Institutions
- University of North Carolina at Chapel Hill (US)
- Central South University (CN)
- Shanghai Jiao Tong University (CN)
- Third Xiangya Hospital (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-10-08
- DOI
- https://doi.org/10.1186/s10020-025-01375-3
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Central South University
- Shanghai Jiao Tong University