Glyuranolide-Dependent Inhibition of NF-κB/Akt Pathways by Sini Decoction Enhances Caspase-3-Mediated Apoptosis in Colorectal Cancer

SND exerts anti-CRC effects through multi-target synergistic mechanisms involving NF-κB/Akt signaling and Caspase-3-mediated apoptosis. Glyuranolide may represent its key active molecule. These findings provide preliminary evidence supporting SND or its derivatives as potential candidates for precision CRC therapy and suggest a strategy to overcome resistance to single-target treatment. Further studies are warranted to confirm the clinical translational value of SND and the specific role of Glyuranolide.