Normative amygdala fMRI response during emotional processing as a trait of depressive symptoms in the UK Biobank
The amygdala response to negative stimuli was associated with an individual's risk of recurrence of depressive episodes, and AD treatment reduced these associations. This study highlights the relevance of amygdala reactivity as a trait, but not a state biomarker for (recurrent) depression. Moreover, it demonstrates the benefit of applying NM in the context of population data.
Authors
- Liesbeth Reneman (ORCID: https://orcid.org/0000-0002-5912-9971)
- Henk A. Marquering (ORCID: https://orcid.org/0000-0002-1414-6313)
- Jolene K. Berg
- Matthan W.A. Caan (ORCID: https://orcid.org/0000-0002-5162-8880)
- Henricus G. Ruhé (ORCID: https://orcid.org/0000-0001-6072-0358)
Institutions
- Radboud University Nijmegen (NL)
- Amsterdam Neuroscience (NL)
- Amsterdam University Medical Centers (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- Psychological Medicine
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1017/s0033291725101797
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- ITEA
- H. Lundbeck A/S
- Eurostars