Associations of positive end-expiratory pressure (PEEP) with extubation failure and clinical outcomes in invasively ventilated patients with acute brain injury: A secondary analysis of the ENIO study
Extubating ABI patients at higher PEEP levels was associated with an increased risk of extubation failure and ICU mortality. However, this association likely reflects underlying respiratory pathology or disease severity. Our findings suggest that PEEP level may serve as a surrogate marker for extubation readiness, rather than a modifiable risk factor, and highlight the need for individualized assessment prior to extubation.
Authors
- Francesca Gualdi
- Marcus Josephus Schultz (ORCID: https://orcid.org/0000-0003-3969-7792)
- Luca Montagnani (ORCID: https://orcid.org/0000-0002-8984-9486)
- Lorenzo Ball (ORCID: https://orcid.org/0000-0002-3876-4730)
- Karim Asehnoune (ORCID: https://orcid.org/0000-0003-1899-3517)
- Raphaël Cinotti (ORCID: https://orcid.org/0000-0001-9217-8532)
- Andrea Loggini (ORCID: https://orcid.org/0000-0001-5479-9442)
- Nicolo’ Antonino Patroniti (ORCID: https://orcid.org/0000-0003-3600-193X)
- Denise Battaglini (ORCID: https://orcid.org/0000-0002-6895-6442)
- Patrícia R. M. Rocco (ORCID: https://orcid.org/0000-0003-1412-7136)
- Chiara Robba
Institutions
- Universidade Federal do Rio de Janeiro (BR)
- Centre Hospitalier Universitaire de Nantes (FR)
- Ospedale Policlinico San Martino (IT)
Publication Details
- Journal
- Journal of Critical Care
- Published
- 2025-10-08
- DOI
- https://doi.org/10.1016/j.jcrc.2025.155274
- Citations
- 7
- Primary Topic
- Respiratory Support and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 10.63