Prevalence and severity of atrial cardiomyopathy in patients with recently diagnosed atrial fibrillation and stroke risk factors and its association with early rhythm control: a secondary analysis of EAST-AFNET 4
This prespecified analysis of the EAST-AFNET 4 trial used baseline left atrial diameter, PR interval, and NT-proBNP to quantify atrial cardiomyopathy in patients with recently diagnosed AF. Outcome rates were compared between atrial cardiomyopathy categories, and interactions between atrial cardiomyopathy and early rhythm-control were determined. Most patients had atrial cardiomyopathy (84% with enlarged left atria). Patients with advanced atrial cardiomyopathy had higher rates of primary outcome during follow-up. Early rhythm control was effective with and without atrial cardiomyopathy (Pinteraction = 0.160).
Authors
- Lars Eckardt (ORCID: https://orcid.org/0000-0002-3735-8503)
- A. John Camm (ORCID: https://orcid.org/0000-0002-2536-2871)
- Andreas Goette (ORCID: https://orcid.org/0000-0002-8223-7209)
- Günter Breithardt (ORCID: https://orcid.org/0000-0001-7574-8900)
- Katrin Borof
- Ulrich Schotten (ORCID: https://orcid.org/0000-0003-1532-3315)
- Paulus Kirchhof (ORCID: https://orcid.org/0000-0002-1881-0197)
- Larissa Fabritz (ORCID: https://orcid.org/0000-0002-9241-1733)
- Andreas Metzner (ORCID: https://orcid.org/0000-0002-6818-6396)
- Antonia Zapf (ORCID: https://orcid.org/0000-0002-8467-0508)
- Stephan Willems (ORCID: https://orcid.org/0000-0002-8890-5749)
- Renate B. Schnabel (ORCID: https://orcid.org/0000-0001-7170-9509)
- Harry J.G.M. Crijns (ORCID: https://orcid.org/0000-0003-1073-5337)
- Marc D. Lemoine (ORCID: https://orcid.org/0000-0002-3799-7962)
Institutions
- Universität Hamburg (DE)
- St George's, University of London (GB)
- Maastricht University Medical Centre (NL)
- University Hospital Münster (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- Atrial Fibrillation NETwork (DE)
- Asklepios Klinik St. Georg (DE)
- St. Vincenz-Krankenhaus Limburg (DE)
- Otto-von-Guericke-Universität Magdeburg (DE)
Publication Details
- Journal
- EP Europace
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1093/europace/euaf256
- Citations
- 5
- Primary Topic
- Atrial Fibrillation Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 6.94
Funders
- Sanofi
- Deutsches Zentrum für Herz-Kreislaufforschung
- Kompetenznetz Vorhofflimmern
- British Heart Foundation
- European Commission
- Fondation Leducq
- Deutsche Herzstiftung