Serum Neurofilament Light Chain Correlates With Clinical Severity and Predicts Mortality in Anti-IgLON5 Disease
In anti-IgLON5 disease, serum NfL and GFAP are elevated and correlate with the clinical severity, especially of bulbar symptoms. In clinical practice, serum NfL could be useful for disease monitoring and to predict the risk of death.
Authors
- Françoise Bouhour (ORCID: https://orcid.org/0000-0002-4005-1537)
- Antonio Farina (ORCID: https://orcid.org/0000-0002-5551-0185)
- Virginie Desestret (ORCID: https://orcid.org/0000-0001-9643-1558)
- E Bernard (ORCID: https://orcid.org/0000-0002-3952-9265)
- Linda Pons (ORCID: https://orcid.org/0000-0002-3407-8311)
- Marie Bénaiteau (ORCID: https://orcid.org/0009-0005-2347-6006)
- Sophie Trouillet‐Assant (ORCID: https://orcid.org/0000-0001-6439-4705)
- Géraldine Picard (ORCID: https://orcid.org/0000-0003-1282-267X)
- Stéphane Thobois (ORCID: https://orcid.org/0000-0002-9639-6702)
- Krzysztof Smolik (ORCID: https://orcid.org/0009-0000-2682-6810)
- Macarena Villagrán‐García (ORCID: https://orcid.org/0000-0001-9236-2428)
- Jérôme Honnorat (ORCID: https://orcid.org/0000-0002-4721-5952)
- Bastien Joubert (ORCID: https://orcid.org/0000-0003-4631-3056)
- Amna Abichou-Klich
- Anne‐Laurie Pinto (ORCID: https://orcid.org/0009-0004-5127-3137)
Institutions
- Université Claude Bernard Lyon 1 (FR)
- University of Modena and Reggio Emilia (IT)
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Santé Publique France (FR)
- Hospices Civils de Lyon (FR)
- Hôpital Pierre Wertheimer (FR)
- Hôpital Lyon Sud (FR)
- Institut NeuroMyoGène (FR)
- Virologie et Pathologies Humaines (FR)
- Centre International de Recherche en Infectiologie (FR)
Publication Details
- Journal
- Neurology Neuroimmunology & Neuroinflammation
- Published
- 2025-10-08
- DOI
- https://doi.org/10.1212/nxi.0000000000200498
- Citations
- 3
- Primary Topic
- Peripheral Neuropathies and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 4.17