Lycopene improves the developmental competence of vitrified-thawed oocytes by reestablishing redox balance and modulating Rock1 expression
Lycopene exerts a protective effect against vitrification-induced oxidative stress by restoring redox homeostasis within oocytes and modulating Rock1 expression during early embryo development. Importantly, lycopene treatment did not compromise offspring health, supporting its potential as a safe adjunct to improve vitrification outcomes.
Authors
- Fanghao Guo
- Yongjian Ma
- Yanquan Li
- Meiling Zhang (ORCID: https://orcid.org/0000-0002-8882-2564)
- Li Zhang (ORCID: https://orcid.org/0000-0001-6603-9838)
- Fangfang Chen (ORCID: https://orcid.org/0000-0002-0854-1667)
- Qing Zhang (ORCID: https://orcid.org/0000-0001-5934-8384)
- Di Sun
- Wen Li (ORCID: https://orcid.org/0000-0001-9468-5570)
- Qianhui Hu (ORCID: https://orcid.org/0009-0005-6837-0635)
- Baicai Yang
- Songmao Li
Institutions
- Shanghai University (CN)
- Shanghai Jiao Tong University (CN)
- International Peace Maternity & Child Health Hospital (CN)
Publication Details
- Journal
- Journal of Assisted Reproduction and Genetics
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1007/s10815-025-03640-0
- Citations
- 1
- Primary Topic
- Reproductive Biology and Fertility
- Type
- article
- Field-Weighted Citation Impact
- 1.88
Funders
- Natural Science Foundation of Shanghai
- National Natural Science Foundation of China
- Shanghai Jiao Tong University
- Shanghai Hospital Development Center
- Wu Jieping Medical Foundation