Risk of Seizure Associated With Concomitant Use of Tramadol and Antidepressants in Older Nursing Home Residents
This study provides Class II evidence that the combination of tramadol and CYP2D6-inhibiting antidepressants is associated with a higher risk of seizures compared with the combination of tramadol and CYP2D6-neutral antidepressants.
Authors
- Michael J. Daniels (ORCID: https://orcid.org/0000-0002-9856-9486)
- Yu‐Jung Jenny Wei (ORCID: https://orcid.org/0000-0001-8861-6907)
- Siegfried Schmidt (ORCID: https://orcid.org/0000-0001-5941-6009)
- Stephan Schmidt (ORCID: https://orcid.org/0000-0002-4998-1167)
- Almut G. Winterstein (ORCID: https://orcid.org/0000-0002-6518-5961)
- Roger Benton Fillingim (ORCID: https://orcid.org/0000-0002-7699-8183)
- Steven T. DeKosky (ORCID: https://orcid.org/0000-0003-3743-2758)
Institutions
- Allen Institute for Brain Science (US)
- Center for Drug Evaluation and Research (US)
- American Association of Colleges of Pharmacy (US)
- University of Florida Health (US)
- University of Florida (US)
- The Ohio State University (US)
- University of Florida Health Science Center (US)
- Florida College (US)
Publication Details
- Journal
- Neurology
- Published
- 2025-10-08
- DOI
- https://doi.org/10.1212/wnl.0000000000214270
- Primary Topic
- Anesthesia and Sedative Agents
- Type
- article
- Field-Weighted Citation Impact
- 0.00