Efficacy and Safety of BL-B01D1 in Patients With Locally Advanced or Metastatic Urothelial Carcinoma: A Phase II Clinical Trial
BL-B01D1 showed promising preliminary efficacy and a favorable safety profile at 2.2 mg/kg in patients with la/mUC who had progressed after systemic therapy. These results suggest that BL-B01D1 could be a promising new agent for patients with la/mUC with few treatment options.
Authors
- Xiaojie Bian
- Zhongquan Sun
- Xuepei Zhang (ORCID: https://orcid.org/0000-0003-0919-5871)
- Xiaolin Wang (ORCID: https://orcid.org/0000-0001-5029-982X)
- Sa Xiao (ORCID: https://orcid.org/0000-0002-4574-1406)
- Changlu Hu (ORCID: https://orcid.org/0000-0003-4106-3916)
- Zhixian Yu (ORCID: https://orcid.org/0000-0002-1226-7891)
- Yu Chen (ORCID: https://orcid.org/0000-0003-4293-1324)
- Kai Yao
- Manming Cao (ORCID: https://orcid.org/0000-0003-1805-0922)
- Qin Yang (ORCID: https://orcid.org/0000-0003-1091-2954)
- Tiejun Yang (ORCID: https://orcid.org/0000-0002-9635-1707)
- Yin Huaqi
- Yi Zhu
- Bin Hu (ORCID: https://orcid.org/0000-0002-8509-6069)
- Dingwei Ye (ORCID: https://orcid.org/0000-0003-4974-3780)
- Bin Fu (ORCID: https://orcid.org/0000-0003-0547-3061)
- Lin Jing (ORCID: https://orcid.org/0000-0002-3759-4442)
- Nan Liu (ORCID: https://orcid.org/0009-0008-0767-9788)
- Qingyun Zhang (ORCID: https://orcid.org/0000-0002-7269-7009)
- Hai Zhu (ORCID: https://orcid.org/0009-0003-1516-0998)
- Shusuan Jiang
Institutions
- Shanghai Medical College of Fudan University (CN)
- Nanchang University (CN)
- Sun Yat-sen University (CN)
- Chongqing University (CN)
- Guangxi Medical University (CN)
- Kunming Medical University (CN)
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- Fudan University Shanghai Cancer Center (CN)
- Huadong Hospital (CN)
- Nantong Tumor Hospital (CN)
- Hunan Cancer Hospital (CN)
- Zhujiang Hospital (CN)
- Chengdu University (CN)
- Buchang Pharma (China) (CN)
- Anhui Provincial Hospital (CN)
- Henan Cancer Hospital (CN)
- Sun Yat-sen University Cancer Center (CN)
- Fujian Provincial Cancer Hospital (CN)
- Chongqing Cancer Hospital (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
- Liaoning Cancer Hospital & Institute (CN)
- First Affiliated Hospital of Nanchang University (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Journal of Clinical Oncology
- Published
- 2025-10-08
- DOI
- https://doi.org/10.1200/jco-25-00109
- Citations
- 4
- Primary Topic
- Bladder and Urothelial Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 8.03