Efficiency of aqueous extract of Ganoderma lucidum against Ketoprofen-induced hepatotoxicity in male rats

This study investigates the potential benefits of using Ganoderma lucidum (GL) aqueous extract to mitigate the hepatotoxicity of ketoprofen (KP) in male albino rats. A common non-steroidal anti-inflammatory drug, KP, has hepatotoxicity and other side effects. The therapeutic potential of GL, a medicinal mushroom with anti-inflammatory and antioxidant properties, was evaluated through biochemical studies. Four groups of 28 male albino rats were formed: a control group (G1), a group that received GL alone (300 mg/kg BW/day/ 4 weeks) (G2), a group that received KP alone (50 mg/kg BW/day/ 2 weeks) (G3), and a therapeutic group that received KP (50 mg/kg BW/ day/ 2weeks) and then GL (300 mg/kg BW/ day/ 4 weeks) (G4). According to the findings, administering KP resulted in notable hepatotoxic effects, including increased ALT and AST levels with nonsignificant differences in TB and ALP. These biochemical changes were considerably lessened by GL therapy, especially in the therapeutic group. GL may be used to repair KP-induced hepatotoxicity, as seen by the normalized enzyme levels. This study demonstrates the effectiveness of GL as a natural antioxidant and medicinal substance. The results support its use in treating hepatotoxicity caused by NSAID intoxication. Keywords: Liver; ketoprofen; Ganoderma lucidum; Rats