Dipsticks and point-of-care Microscopy in Urinary Tract Infections in primary care: Results of the MicUTI pilot cluster randomised controlled trial
The POCT-guided management approach for suspected uUTIs is feasible but presents implementation and methodological challenges. Recruitment varied across sites and was lower in the control group practices, highlighting the risk of differential recruitment. Retention was below the expected 80%, indicating the need for efficient follow-up strategies in future trials. Explorative analyses suggest that simply adding diagnostic information may not support antibiotic stewardship. Novel POCTs should be carefully assessed for their influence on prescribing before routine use. Trial registration: ClinicalTrials.gov NCT05667207.
Authors
- Christian Kretzschmann
- Adolfo Figueiras (ORCID: https://orcid.org/0000-0002-5766-8672)
- Anne Simmenroth (ORCID: https://orcid.org/0000-0002-3521-1225)
- Thiên‐Trí Lâm (ORCID: https://orcid.org/0000-0003-3001-0149)
- Guido Schmiemann (ORCID: https://orcid.org/0000-0002-2846-6561)
- Peter K Kurotschka (ORCID: https://orcid.org/0000-0003-3750-6147)
- Alexander Hapfelmeier (ORCID: https://orcid.org/0000-0001-6765-6352)
- Oliver Kurzai (ORCID: https://orcid.org/0000-0002-7277-2646)
- Martin J. Koch (ORCID: https://orcid.org/0000-0001-6165-0785)
- Ildikó Gágyor (ORCID: https://orcid.org/0000-0002-7974-7603)
- Orietta Massidda (ORCID: https://orcid.org/0000-0001-8823-2372)
- Eva Bucher
- Antonius Schneider (ORCID: https://orcid.org/0000-0002-2847-8626)
- Alastair D Hay (ORCID: https://orcid.org/0000-0003-3012-375X)
- Mark H. Ebell (ORCID: https://orcid.org/0000-0003-3228-2877)
- Lisette Warkentin (ORCID: https://orcid.org/0000-0002-6241-6082)
- Linda Sanftenberg (ORCID: https://orcid.org/0000-0002-3174-5297)
- Stefanie Stark (ORCID: https://orcid.org/0000-0002-5349-7984)
- Jochen Stefan Gensichen (ORCID: https://orcid.org/0000-0002-1347-2862)
- Kathrin Lasher
Institutions
- University of Bremen (DE)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- University of Trento (IT)
- Universidade de Santiago de Compostela (ES)
- University of Würzburg (DE)
- LMU Klinikum (DE)
- Michigan United (US)
- Universitätsklinikum Würzburg (DE)
- Primary Health Care (QA)
- Technical University of Munich (DE)
- Ludwig-Maximilians-Universität München (DE)
- Michigan State University (US)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-10-08
- DOI
- https://doi.org/10.1371/journal.pone.0332390
- Primary Topic
- Urinary Tract Infections Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00