Crosstalk between liver sinusoidal endothelial cells and hepatocytes via IL-1α–IL1R1 axis exacerbates ischaemia/reperfusion injury in aged livers
Our findings identify the crosstalk between LSECs and hepatocytes in aged livers aggravating HIRI via MEIS2/IL-1α/IL1R1/TNF-α axis, suggesting that IL-1α neutralising antibody can be exploited as a promising therapeutic strategy for aged HIRI.
Authors
- Jia Yao (ORCID: https://orcid.org/0000-0003-1457-7241)
- Yasong Liu (ORCID: https://orcid.org/0000-0002-9919-2051)
- Jun Zheng (ORCID: https://orcid.org/0000-0002-4283-0403)
- Shuhong Yi (ORCID: https://orcid.org/0000-0003-1837-7837)
- Zhengqi Wu (ORCID: https://orcid.org/0000-0003-2322-6259)
- Xuying Liu (ORCID: https://orcid.org/0000-0001-9190-4651)
- Zhongying Hu (ORCID: https://orcid.org/0000-0002-6312-2940)
- Jiebin Zhang (ORCID: https://orcid.org/0000-0002-2650-6822)
- Qiang You
- Yingcai Zhang (ORCID: https://orcid.org/0000-0002-3086-2440)
- Haitian Chen (ORCID: https://orcid.org/0000-0002-0533-6983)
- Qi Zhang (ORCID: https://orcid.org/0000-0001-9916-8919)
- Yang Yang (ORCID: https://orcid.org/0000-0003-4981-4745)
- Feng Zhang (ORCID: https://orcid.org/0000-0002-1401-9728)
- Tingting Wang (ORCID: https://orcid.org/0000-0002-3385-9036)
- Hua Li (ORCID: https://orcid.org/0000-0001-9388-7883)
- Rong Li (ORCID: https://orcid.org/0000-0003-4951-577X)
- Jiaqi Xiao (ORCID: https://orcid.org/0000-0002-3253-9591)
Institutions
- Sun Yat-sen University (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
Publication Details
- Journal
- Gut
- Published
- 2025-10-08
- DOI
- https://doi.org/10.1136/gutjnl-2025-335964
- Citations
- 2
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.59