Barrier dysfunction in nasal epithelium contributes to persistent inflammation in long COVID
While multiple organ systems are implicated in LC, our findings identified nasal epithelial dysfunction in a subgroup of LC patients and chronic activation as potential contributors to systemic immune dysregulation. The IL-1β-IFN-γ axis represents a novel targetable pathway that may support precision therapies for LC.
Authors
- Cornelis M. van Drunen (ORCID: https://orcid.org/0000-0001-5503-066X)
- Anke H. Maitland‐van der Zee (ORCID: https://orcid.org/0000-0002-0414-3442)
- Milena Sokołowska (ORCID: https://orcid.org/0000-0001-9710-6685)
- Sien T. Verbeek
- Nadia Baalbaki (ORCID: https://orcid.org/0000-0002-8188-7760)
- Daniëlle van Egmond
- Merel E.B. Cornelissen
- Korneliusz Golebski (ORCID: https://orcid.org/0000-0002-4685-4592)
- Patricia Jaeger
Institutions
- University of Zurich (CH)
- Amsterdam Neuroscience (NL)
- Amsterdam University Medical Centers (NL)
- Amsterdam University of Applied Sciences (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- Journal of Allergy and Clinical Immunology
- Published
- 2025-10-08
- DOI
- https://doi.org/10.1016/j.jaci.2025.09.024
- Primary Topic
- Immune Response and Inflammation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Health~Holland
- ZonMw