Aging and Host Responses to Severe Infection: Proteomic Analysis of a Prospective Multicenter Cohort From Uganda
Older age (60 yr old or older) is associated with distinct host responses to severe infection in SSA. These findings may inform development of age-stratified, host-directed treatment strategies for severe infectious diseases.
Authors
- Kai Nie (ORCID: https://orcid.org/0000-0002-8253-9688)
- Joweria Nakaseegu (ORCID: https://orcid.org/0000-0001-9864-0679)
- Barnabas Bakamutumaho (ORCID: https://orcid.org/0000-0003-4259-8509)
- John Kayiwa (ORCID: https://orcid.org/0000-0002-1840-1801)
- Jingjing Qi (ORCID: https://orcid.org/0000-0002-9368-1882)
- Matthew J. Cummings (ORCID: https://orcid.org/0000-0003-2906-0966)
- Alin S. Tomoiaga (ORCID: https://orcid.org/0000-0003-2221-8484)
- Julius J. Lutwama (ORCID: https://orcid.org/0000-0002-3210-722X)
- Gabriel Conte Cortez Martins (ORCID: https://orcid.org/0000-0001-5175-6076)
- Seunghee Kim‐Schulze (ORCID: https://orcid.org/0000-0003-0192-4400)
- Hui Xie (ORCID: https://orcid.org/0000-0002-3941-4150)
- Irene Nayiga
- Martina Cathy Nakibuuka
- Xiaohong Lu (ORCID: https://orcid.org/0000-0001-6417-0250)
- Nicholas Owor
- Stephen Kyebambe
- Max R. O’Donnell (ORCID: https://orcid.org/0000-0002-1232-3718)
- Xiaoyu Che (ORCID: https://orcid.org/0000-0003-0001-4122)
- Walter Ian Lipkin (ORCID: https://orcid.org/0000-0002-8768-9386)
- Steven J. Reynolds (ORCID: https://orcid.org/0000-0002-5403-2759)
- Joseph Shinyale
- Mercy Haumba
- Jesse Ross (ORCID: https://orcid.org/0009-0008-3405-0897)
- Thomas Ochar
- Moses Kiwubeyi
- Rittah Nankwanga
- Christopher Nsereko
- Bryan Villagomez
- Sam Miake-Lye
Institutions
- National Institutes of Health (US)
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- Ministry of Agriculture, Animal Industry and Fisheries (UG)
- Ministry of Health (UG)
- Rakai Health Sciences Program (UG)
- National Institute of Allergy and Infectious Diseases (US)
- Manhattan University (US)
- Columbia University (US)
- Uganda Virus Research Institute (UG)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Critical Care Explorations
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1097/cce.0000000000001330
- Primary Topic
- Immune responses and vaccinations
- Type
- article
- Field-Weighted Citation Impact
- 0.00