Aging and Host Responses to Severe Infection: Proteomic Analysis of a Prospective Multicenter Cohort From Uganda

Older age (60 yr old or older) is associated with distinct host responses to severe infection in SSA. These findings may inform development of age-stratified, host-directed treatment strategies for severe infectious diseases.

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Publication Details

Journal
Critical Care Explorations
Published
2025-10-01
DOI
https://doi.org/10.1097/cce.0000000000001330
Primary Topic
Immune responses and vaccinations
Type
article
Field-Weighted Citation Impact
0.00
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article

Aging and Host Responses to Severe Infection: Proteomic Analysis of a Prospective Multicenter Cohort From Uganda

Kai Nie, Joweria Nakaseegu, Barnabas Bakamutumaho, John Kayiwa et al.
Critical Care Explorations
Immune responses and vaccinations
article

Aging and Host Responses to Severe Infection: Proteomic Analysis of a Prospective Multicenter Cohort From Uganda

Kai Nie, Joweria Nakaseegu, Barnabas Bakamutumaho, John Kayiwa, Jingjing Qi, Matthew J. Cummings, Alin S. Tomoiaga, Julius J. Lutwama, Gabriel Conte Cortez Martins, Seunghee Kim‐Schulze, Hui Xie, Irene Nayiga, Martina Cathy Nakibuuka, Xiaohong Lu, Nicholas Owor, Stephen Kyebambe, Max R. O’Donnell, Xiaoyu Che, Walter Ian Lipkin, Steven J. Reynolds, Joseph Shinyale, Mercy Haumba, Jesse Ross, Thomas Ochar, Moses Kiwubeyi, Rittah Nankwanga, Christopher Nsereko, Bryan Villagomez, Sam Miake-Lye
article en

Abstract

Older age (60 yr old or older) is associated with distinct host responses to severe infection in SSA. These findings may inform development of age-stratified, host-directed treatment strategies for severe infectious diseases.

Critical Care ExplorationsVol. 7(10)
National Institutes of Health (US), Johns Hopkins University (US), Johns Hopkins Medicine (US), Ministry of Agriculture, Animal Industry and Fisheries (UG), Ministry of Health (UG), Rakai Health Sciences Program (UG), National Institute of Allergy and Infectious Diseases (US), Manhattan University (US), Columbia University (US), Uganda Virus Research Institute (UG), Icahn School of Medicine at Mount Sinai (US)
Openalex Percentile: Top 71%
Immune responses and vaccinations
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