Impact of the cytokine milieu on fibroblasts and their characterization in chronic rhinosinusitis with nasal polyps
Fibroblasts contribute to nasal polypogenesis irrespective of inflammation type in CRSwNP. Although their behavior is regulated by the immune microenvironment, our findings also highlight fibroblasts as potential therapeutic targets, supporting both endotypic classification and novel treatment strategies.
Authors
- Hideyuki Takahashi (ORCID: https://orcid.org/0000-0002-2465-3992)
- Toshiyuki Matsuyama (ORCID: https://orcid.org/0000-0001-7043-3942)
- Masaomi Motegi (ORCID: https://orcid.org/0000-0003-0947-6526)
- Reika Kawabata‐Iwakawa (ORCID: https://orcid.org/0000-0002-3504-1393)
- Kazuaki Chikamatsu (ORCID: https://orcid.org/0000-0002-7739-0102)
- Yuichi Tomidokoro (ORCID: https://orcid.org/0009-0001-9628-4436)
Institutions
- Gunma University (JP)
Publication Details
- Journal
- Acta Oto-Laryngologica
- Published
- 2025-10-08
- DOI
- https://doi.org/10.1080/00016489.2025.2567407
- Primary Topic
- Sinusitis and nasal conditions
- Type
- article
- Field-Weighted Citation Impact
- 0.00