Comparative Transcriptomic Profiling of Corneal Compartments Using Single-Cell and Single-Nucleus Sequencing
Collectively, our findings provide an objective evaluation of scRNA-seq and snRNA-seq performance across corneal cell types, offering practical guidance for selecting optimal sequencing strategies based on specific research requirements.
Authors
- Hongran Zhao (ORCID: https://orcid.org/0000-0001-8571-785X)
- Shengqian Dou (ORCID: https://orcid.org/0000-0002-8087-0115)
- Qingjun Zhou (ORCID: https://orcid.org/0000-0002-6109-3445)
- Xiaoyu Li (ORCID: https://orcid.org/0000-0001-8017-207X)
- Lixin Xie (ORCID: https://orcid.org/0009-0006-8117-2067)
- Xiaowen Zhang
Institutions
- Shandong Eye Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-10-08
- DOI
- https://doi.org/10.1167/iovs.66.13.11
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.00