Preclinical Evaluation of Pitavastatin Nanoparticles for Preserving Cone Photoreceptors in Mouse Models of RP
Monthly intravenous administration of PVS-NPs may be an effective treatment regimen to delay cone-cell degeneration in RP. The therapeutic effect of PVS-NPs likely involves the modulation of circulating inflammatory monocytes and their engraftment.
Authors
- Keijiro Ishikawa (ORCID: https://orcid.org/0000-0002-4590-4471)
- Yusuke Murakami (ORCID: https://orcid.org/0000-0002-3761-1732)
- Masatoshi Fukushima
- Sakurako Shimokawa
- Jun Funatsu (ORCID: https://orcid.org/0000-0002-7418-1401)
- Chie Kikutake (ORCID: https://orcid.org/0000-0002-9571-641X)
- Mikita Suyama (ORCID: https://orcid.org/0000-0001-9526-3193)
- Takahiro Hisai
- Mitsuru Arima (ORCID: https://orcid.org/0000-0002-6081-8133)
- Koh-Hei Sonoda
- Kaori Tanaka (ORCID: https://orcid.org/0000-0002-8887-4217)
- Shotaro Shimokawa (ORCID: https://orcid.org/0000-0002-7255-3443)
- Yasuyuki Ohkawa (ORCID: https://orcid.org/0000-0001-6440-9954)
- Shoji Notomi (ORCID: https://orcid.org/0000-0002-7935-4244)
- Tao Yan (ORCID: https://orcid.org/0000-0003-3139-6813)
- Huanyu Zhao
Institutions
- Kyushu University (JP)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-10-08
- DOI
- https://doi.org/10.1167/iovs.66.13.15
- Primary Topic
- Retinoids in leukemia and cellular processes
- Type
- article
- Field-Weighted Citation Impact
- 0.00