Behavioral and transcriptional effects of age in HbSS-BERK humanized SCD mice
This study offers a comprehensive approach to investigate candidate drugs to treat SCD pain and explores biomarkers associated with the HbSS SCD mouse model. Although oxycodone ameliorated the hyper-nociceptive phenotype of HbSS mice, it failed to restore functional behavior, underscoring the need to identify novel therapeutic strategies that effectively reduce pain and restore functional behavior.
Authors
- Bryan McKiver (ORCID: https://orcid.org/0000-0002-1447-5803)
- Molly Sonenklar
- M. Taylor
- Kalpna Gupta (ORCID: https://orcid.org/0000-0001-9381-9979)
- Aron H. Lichtman (ORCID: https://orcid.org/0000-0001-5601-985X)
- Karan H. Muchhala (ORCID: https://orcid.org/0000-0002-2594-1347)
- Hamid I. Akbarali (ORCID: https://orcid.org/0000-0003-1423-0774)
- Kennedy Goldsborough (ORCID: https://orcid.org/0000-0001-9403-2721)
- Wally R. Smith (ORCID: https://orcid.org/0000-0002-4122-5367)
- Adwoa Agyemang Adu-Gyamfi (ORCID: https://orcid.org/0000-0001-7921-8800)
- Sara M Herz (ORCID: https://orcid.org/0009-0004-8763-5670)
- M. Imad Damaj (ORCID: https://orcid.org/0000-0002-8859-029X)
- Donald K. Jessup
- Joyce A. Lloyd (ORCID: https://orcid.org/0000-0003-0952-9923)
Institutions
- Virginia Commonwealth University (US)
- University of California, Irvine (US)
- Louisiana State University Health Sciences Center New Orleans (US)
Publication Details
- Journal
- Journal of sickle cell disease.
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1093/jscdis/yoaf033
- Primary Topic
- Hemoglobinopathies and Related Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- CSL Behring
- Grifols
- National Institutes of Health
- School of Medicine, Virginia Commonwealth University