Differential contributions of cardiovascular health-related lifestyle factors to epigenetic ageing: implications for healthy longevity
Simultaneous improvements in multiple CVH components were associated with lower EAA, with sex-specific differences in the most influential factors. Tailored health strategies-emphasizing smoking cessation and glucose control for males, and physical activity, glucose control, and weight management for females-may help slow ageing. These findings highlight the need for public and clinical interventions that incorporate sex differences in health behaviours and the potential biological mechanisms of ageing.
Authors
- Sung‐Il Cho (ORCID: https://orcid.org/0000-0003-4085-1494)
- Da-eun Lee (ORCID: https://orcid.org/0000-0002-8821-127X)
- Kyeezu Kim (ORCID: https://orcid.org/0000-0002-9094-9011)
- Yi Seul Park (ORCID: https://orcid.org/0009-0009-9139-0393)
- Hye-Mi Jang (ORCID: https://orcid.org/0000-0001-8744-0487)
- Young‐Jin Kim (ORCID: https://orcid.org/0000-0001-6505-9212)
- Bong-Jo Kim (ORCID: https://orcid.org/0000-0003-3562-2654)
Institutions
- Northwestern University (US)
- Seoul National University (KR)
- Korea National Institute of Health (KR)
- National University College (PR)
- Sungkyunkwan University (KR)
Publication Details
- Journal
- BMC Medicine
- Published
- 2025-10-08
- DOI
- https://doi.org/10.1186/s12916-025-04394-3
- Citations
- 2
- Primary Topic
- Birth, Development, and Health
- Type
- article
- Field-Weighted Citation Impact
- 6.99
Funders
- National Research Foundation
- National Research Foundation of Korea