Amino acid-assisted green synthesis of a porous binary oxide nanocomposite for sensitive electrochemical detection of chlorpromazine

In this work, an eco-friendly method was used to synthesize cerium-bismuth oxide nanostructures as a binary oxide nanocomposite. For this purpose, L-alanine was utilized as a novel and green fuel to produce a nanostructured Bi₂O₃-CeO₂ sample. The prepared porous CeO₂-Bi₂O₃ NPs and ionic liquid were used to develop a new sensor (Pr-CeO₂-Bi₂O₃/IL/CPE) for detecting Chlorpromazine (CLP). The study showed that the present electrode has good electrochemical performance for CLP detection under a diffusion-controlled procedure. The chronoamperometric method was utilized to calculate the diffusion coefficient (D) of CLP, which was found to be 1.47 × 10^-5 cm² s^{- 1}. The DPV technique was employed to establish the calibration curve, demonstrating a linear range of 0.02-140 µM and achieving a detection limit (LOD) of 9 nM. The prepared sensor also showed suitable repeatability and reproducibility. The practical applicability of Pr-CeO₂-Bi₂O₃/IL/CPE for detecting CLP in various real samples showed good sensitivity and selectivity.