Herpesviruses Reactivation and Systemic Inflammation Before and After Initiating Antiretroviral Therapy Among Women with HIV in Rakai, Uganda
Although ART initiation was not associated with increased herpesvirus shedding overall, CMV shedding increased in women with advanced HIV-1. The association of mucosal shedding of CMV, HSV-2, and KSHV in post-ART timepoints with different baseline biomarkers of systemic inflammation suggest that distinct immunological functions are implicated in the control of their viral replication.
Authors
- Adam Rupert (ORCID: https://orcid.org/0000-0002-3778-9856)
- Viviane Callier
- Sanchita Basu Das (ORCID: https://orcid.org/0000-0002-2246-7942)
- Thomas C. Quinn (ORCID: https://orcid.org/0000-0002-0404-1315)
- Taddeo Kityamuweesi
- Stephen Tomusange
- Martha Nason (ORCID: https://orcid.org/0000-0002-0110-881X)
- Aggrey Anok (ORCID: https://orcid.org/0000-0002-6320-6394)
- Andrea Lisco (ORCID: https://orcid.org/0000-0002-1475-356X)
- Andrea Towlerton (ORCID: https://orcid.org/0000-0002-7472-789X)
- Victor Ssempijja (ORCID: https://orcid.org/0000-0003-2609-6525)
- Lorenzo Walker
- Andrew D. Redd (ORCID: https://orcid.org/0000-0003-4651-1423)
- Irini Sereti (ORCID: https://orcid.org/0000-0002-0076-0224)
- Steven J. Reynolds (ORCID: https://orcid.org/0000-0002-5403-2759)
- Paul Bbuule
Institutions
- National Institutes of Health (US)
- Johns Hopkins University (US)
- University of Cape Town (ZA)
- Johns Hopkins Medicine (US)
- Hutchinson Centre Research Institute in Uganda (UG)
- Rakai Health Sciences Program (UG)
- Frederick National Laboratory for Cancer Research (US)
- National Institute of Allergy and Infectious Diseases (US)
- Wellcome Centre for Infectious Diseases Research in Africa (ZA)
Publication Details
- Journal
- Open Forum Infectious Diseases
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1093/ofid/ofaf603
- Primary Topic
- HIV/AIDS Research and Interventions
- Type
- article
- Field-Weighted Citation Impact
- 0.00