Mitochondria‐Targeted Delivery of siRNA by Amphiphilic Nanovectors Self‐Assembled from a Cationic [4]Helicene‐Squalene Ester
The active delivery of therapeutic nucleic acids with subcellular precision is an open challenge. Herein, a small conjugate molecule, combining a cationic [4]helicene moiety with a lipophilic squalene tail, yields amphiphilic nanoassemblies capable of effectively complexing siRNA within the mitochondria. A proof-of-concept in HCT 116 colorectal cancer cells was evidenced by Western blot for the delivery of siRNA silencing the protein expression of the mitochondria-encoded cytochrome c oxidase subunit 1 gene.
Authors
- Rebecca Mucci (ORCID: https://orcid.org/0000-0001-6453-0404)
- Kévin Martin (ORCID: https://orcid.org/0000-0002-4861-4410)
- Dandan Su (ORCID: https://orcid.org/0000-0001-9220-5473)
- Nadir Bettache (ORCID: https://orcid.org/0000-0001-5426-7024)
- Jérôme Lacour (ORCID: https://orcid.org/0000-0001-6247-8059)
- Lamiaa M. A. Ali (ORCID: https://orcid.org/0000-0003-1176-5335)
- Mihail Bãrboiu (ORCID: https://orcid.org/0000-0003-0042-9483)
- Sébastien Ulrich (ORCID: https://orcid.org/0000-0002-6080-3345)
Institutions
- University of Geneva (CH)
- Centre National de la Recherche Scientifique (FR)
- Institut des Biomolécules Max Mousseron (FR)
- Institut Européen des Membranes (FR)
Publication Details
- Journal
- ChemBioChem
- Published
- 2025-10-07
- DOI
- https://doi.org/10.1002/cbic.202500537
- Citations
- 1
- Primary Topic
- Supramolecular Self-Assembly in Materials
- Type
- article
- Field-Weighted Citation Impact
- 0.60
Funders
- National Science Foundation
- Biogen
- Agence Nationale de la Recherche
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Fondation ARC pour la Recherche sur le Cancer
- Centre National de la Recherche Scientifique
- Université de Genève