Precision periodontics: A new era of data‑driven periodontal care (Review)

Precision periodontics represents a paradigm shift in periodontal care by embracing personalized, data‑driven strategies to manage periodontal diseases. Moving beyond traditional diagnostic methods, this approach integrates genomic, proteomic, microbiomic and environmental data to tailor prevention and treatment to individual patient profiles. The present review discusses precision periodontics and its role in data‑driven periodontal care. With periodontitis affecting almost half the global adult population, the urgency for more effective, personalized interventions is evident. Innovations in omics technologies have enabled the identification of genetic markers, microbial dysbiosis patterns and inflammatory biomarkers, enhancing diagnostic accuracy and risk stratification. Salivary diagnostics and next‑generation sequencing provide non‑invasive tools for real‑time assessment, while point‑of‑care technologies provide rapid, chairside evaluations. Digital advancements, such as electronic health records, wearable devices, teledentistry and artificial intelligence‑driven analytics, further support personalized care by improving data integration, monitoring and patient engagement. Treatment modalities, including microbiome‑guided antimicrobials, pharmacogenomics‑based drug regimens, minimally invasive procedures and biomaterial‑guided regeneration, demonstrate how precision periodontics optimizes outcomes and reduces overtreatment. The clinical benefits include early detection, the better management of complex cases, and enhanced patient adherence to care plans. Despite challenges, such as cost and accessibility, precision periodontics holds transformative potential to reduce global oral health disparities. Its successful implementation will require collaboration among clinicians, researchers, and educators to advance innovation and ensure equitable access. Ultimately, precision periodontics promises to redefine the future of periodontal therapy by providing more effective, personalized and inclusive therapeutics.6