Novel differentially expressed genes and multiple biological pathways for Alzheimer's disease identified in brain tissue from African American donors
We performed the largest African American brain tissue Alzheimer's disease (AD) gene expression study. Expression differences for 482 genes, notably ADAMTS2, were study-wide significant. Many significant differentially expressed genes are involved in energy metabolism. Several previously known AD-associated variants in African Americans are eQTLs. These results advance knowledge of the genetic basis of AD in the AA population.
Authors
- Julia Kofler (ORCID: https://orcid.org/0000-0003-4298-7328)
- Margaret E. Flanagan (ORCID: https://orcid.org/0009-0008-7078-3545)
- Matthew P. Frosch (ORCID: https://orcid.org/0000-0002-3940-9861)
- Dennis W. Dickson (ORCID: https://orcid.org/0000-0001-7189-7917)
- Richard J. Perrin (ORCID: https://orcid.org/0000-0002-3443-7716)
- Shih‐Hsiu J. Wang (ORCID: https://orcid.org/0000-0002-0358-8159)
- Peter T. Nelson (ORCID: https://orcid.org/0000-0002-6161-1265)
- Mark W. Logue (ORCID: https://orcid.org/0000-0001-9347-7892)
- Julie A. Schneider (ORCID: https://orcid.org/0000-0003-0756-5007)
- Thor D. Stein (ORCID: https://orcid.org/0000-0001-6954-4477)
- Brittany N. Dugger (ORCID: https://orcid.org/0000-0003-2141-8855)
- Ann C. McKee (ORCID: https://orcid.org/0000-0003-2961-7488)
- Adam Labadorf (ORCID: https://orcid.org/0000-0002-0753-8992)
- Lindsay A. Farrer (ORCID: https://orcid.org/0000-0001-5533-4225)
- Melissa E. Murray (ORCID: https://orcid.org/0000-0001-7379-2545)
- Juan C. Troncoso (ORCID: https://orcid.org/0000-0001-9553-6673)
- Andrew F. Teich (ORCID: https://orcid.org/0000-0002-1916-8490)
- Benjamin L. Wolozin (ORCID: https://orcid.org/0000-0003-2068-1475)
- Richard P Mayeux (ORCID: https://orcid.org/0000-0001-6519-9696)
- Jesse Mez (ORCID: https://orcid.org/0000-0003-1438-5442)
- Zihan Wang (ORCID: https://orcid.org/0000-0001-8193-7054)
- Nicholas K. O’Neill (ORCID: https://orcid.org/0000-0002-9953-9940)
- Lee‐Way Jin
- Carol A. Miller
- Marla Gearing
- Katarnut Tobunluepop
Institutions
- Boston University (US)
- Northwestern University (US)
- University of Southern California (US)
- Rush University Medical Center (US)
- University of Kentucky (US)
- Johns Hopkins University (US)
- Emory University (US)
- University of Pittsburgh (US)
- Washington University in St. Louis (US)
- Columbia University Irving Medical Center (US)
- Johns Hopkins Medicine (US)
- Emory University Hospital (US)
- Jacksonville College (US)
- VA Boston Healthcare System (US)
- University of Massachusetts Boston (US)
- Massachusetts General Hospital (US)
- National Center for PTSD (US)
- Duke Medical Center (US)
- University of California Davis Medical Center (US)
- Columbia University (US)
- University of California, Davis (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1002/alz.70629
- Citations
- 1
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.16