Metabolic and vascular contributions to dementia: Soluble epoxide hydrolase‐derived linoleic acid oxylipins and glycemic status are related to cerebral small vessel disease markers, atrophy, and cognitive performance
LA-derived sEH metabolite (diol) to substrate (epoxide) ratio was lower in individuals with diabetes. The diol/epoxide ratio with high HbA1c contributed to SVD and brain atrophy. The CYP450-sEH pathway may link metabolic and vascular contributions to dementia. sEH may be a potential therapeutic target in individuals with diabetes.
Authors
- Anthony E. Lang (ORCID: https://orcid.org/0000-0003-1229-3667)
- Hugo Cogo‐Moreira (ORCID: https://orcid.org/0000-0001-9411-9237)
- Bradley J. MacIntosh (ORCID: https://orcid.org/0000-0001-7300-2355)
- Stephen R. Arnott (ORCID: https://orcid.org/0000-0002-0616-7771)
- Nuanyi Liang (ORCID: https://orcid.org/0000-0002-6802-5015)
- Robert A. Hegele (ORCID: https://orcid.org/0000-0003-2861-5325)
- Ameer Y. Taha (ORCID: https://orcid.org/0000-0003-4611-7450)
- Jennifer S. Rabin (ORCID: https://orcid.org/0000-0003-4754-2221)
- Maged Goubran (ORCID: https://orcid.org/0000-0001-5880-0818)
- Sean Symons (ORCID: https://orcid.org/0000-0002-8025-9965)
- Krista L. Lanctôt (ORCID: https://orcid.org/0000-0001-7024-6637)
- Julie Ottoy (ORCID: https://orcid.org/0000-0002-9879-7497)
- Walter Swardfager (ORCID: https://orcid.org/0000-0002-0030-8908)
- Anthony M. Magliocco
- Joel Ramirez (ORCID: https://orcid.org/0000-0002-5582-1776)
- Natasha Z. Anita (ORCID: https://orcid.org/0009-0007-9179-1539)
- Myuri Ruthirakuhan (ORCID: https://orcid.org/0000-0003-0308-2593)
- William Z. Lin (ORCID: https://orcid.org/0000-0002-3610-5213)
- Yuen Yan Wong (ORCID: https://orcid.org/0000-0002-9567-5304)
- Si Won Ryoo
- C. Huang
- Sofia E. Perfetto
Institutions
- Western University (CA)
- Sunnybrook Health Science Centre (CA)
- University Health Network (CA)
- University of Toronto (CA)
- Østfold University of Applied Sciences (NO)
- Toronto Western Hospital (CA)
- Toronto Rehabilitation Institute (CA)
- Health Sciences Centre (CA)
- University of California San Diego (US)
- Occupational Cancer Research Centre (CA)
- Indoc Research (CA)
- Sunnybrook Hospital (CA)
- Krembil Research Institute
- Sunnybrook Research Institute
- University of California, Davis (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1002/alz.70718
- Primary Topic
- Eicosanoids and Hypertension Pharmacology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Alzheimer's Association
- Eli Lilly and Company
- BrightFocus Foundation
- University of Ottawa
- Fondation Brain Canada
- McMaster University
- Weston Brain Institute
- Government of Ontario
- Centre for Addiction and Mental Health Foundation
- Fondation Leducq
- Canada Research Chairs
- Queen's University
- University of Toronto
- Temerty Family Foundation
- Ministry of Colleges and Universities
- National Institute of Food and Agriculture
- Canadian Institutes of Health Research
- Natural Sciences and Engineering Research Council of Canada
- Banting and Best Diabetes Centre, University of Toronto
- Faculty of Health Sciences, Queen's University