MyClone: rapid and precise reconstruction of clonal population structures for tumors
For deeply sequenced data, MyClone outperforms existing methods on both targeted sequencing and bulk tumor data. Its high computational efficiency and reconstruction accuracy position MyClone as a promising tool for broad clinical application in cancer treatment. The source code is publicly available at https://github.com/Hansen0413/myclone-code .
Authors
- Fei Ma (ORCID: https://orcid.org/0000-0001-9432-1902)
- Dan Lv (ORCID: https://orcid.org/0009-0008-5758-8112)
- Haili Qian (ORCID: https://orcid.org/0000-0003-0652-4801)
- Bo Lan (ORCID: https://orcid.org/0000-0002-2962-439X)
- Qiyong Guo (ORCID: https://orcid.org/0000-0002-7983-3093)
- Ting Chen
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- National Cancer Center (US)
- Liaoning Cancer Hospital & Institute (CN)
- China Medical University (CN)
- Tsinghua University (CN)
Publication Details
- Journal
- BMC Bioinformatics
- Published
- 2025-10-08
- DOI
- https://doi.org/10.1186/s12859-025-06252-8
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Key Research and Development Program of China