Isthmin 1, matrix metalloproteinase 8 and asprosin as potential biomarkers in periodontitis with obesity

In conclusion, circulating levels of ISM1 and MMP-8 were significantly elevated in patients with obesity and positively correlated with BMI. Importantly, our study demonstrates that ISM1 and MMP-8 levels in GCF reflect the severity of periodontitis, as evidenced by their strong positive association with clinical parameters such as PD and CAL. Non-invasive method of testing ISM1, MMP-8 and asprosin could be an effective reference tool for evaluating periodontitis in patients with obesity. All in all, ISM1, MMP-8 and asprosin might be potential biomarkers in periodontitis with obesity.