Tumor matrix stiffness drives malignant progression in murine breast cancer: enhanced stemness, tumorigenesis and metastasis
An alginate–chitosan scaffold mimicking tumoral matrix stiffness promotes breast cancer cell growth, increases stemness, and imprints a persistent mechanical memory that enhances tumorigenesis and metastasis in a murine model.
Authors
- Masoumeh Dehghan Manshadi
- Zahra Madjd (ORCID: https://orcid.org/0000-0001-7329-2583)
- Mazaher Gholipourmalekabadi (ORCID: https://orcid.org/0000-0001-6287-6831)
- Samane Heydari
- Roya Ghods (ORCID: https://orcid.org/0000-0001-5996-3758)
- Farhang Sasani (ORCID: https://orcid.org/0000-0003-1167-1785)
- Behnaz Ashtari (ORCID: https://orcid.org/0000-0001-9554-3232)
- Farideh Hashemi (ORCID: https://orcid.org/0000-0002-4865-3727)
- Mehran Vosoogh
- Sadegh Safaei
Institutions
- Iran University of Medical Sciences (IR)
- University of Tehran (IR)
- Academic Center for Education, Culture and Research (IR)
Publication Details
- Journal
- Materials Advances
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5ma00664c
- Primary Topic
- Cellular Mechanics and Interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science Foundation
- Iran University of Medical Sciences
- Iran National Science Foundation