BMAL1 modulation alleviates inflammatory responses in monocytes by targeting the Fis1-mediated mitochondrial unfolded protein response in high-altitude hypoxia
Our findings indicate that transcriptional activation of Bmal1 in monocytes can potentially serve as a novel biomarker of hypoxia-induced inflammation. Our findings also suggest a novel approach for modulating the intrinsic clock, which might render organisms less vulnerable to high-altitude hypoxia.
Authors
- Xiongwen Chen (ORCID: https://orcid.org/0000-0002-3829-5815)
- Lin Zhang (ORCID: https://orcid.org/0000-0002-9295-1684)
- Zhi‐Bin Yu (ORCID: https://orcid.org/0000-0001-5357-9288)
- Cai Yue (ORCID: https://orcid.org/0000-0001-5754-0225)
- Peijie Li (ORCID: https://orcid.org/0000-0002-3203-0904)
- Man‐Jiang Xie
- Ying-Rui Bu
- Bin Zhang (ORCID: https://orcid.org/0000-0002-6286-6227)
- Jin Xu (ORCID: https://orcid.org/0000-0001-7713-1971)
- Siyuan He
- Yong Liu (ORCID: https://orcid.org/0000-0001-6761-3344)
- Yiling Ge
- Heng Ma (ORCID: https://orcid.org/0000-0002-1893-0658)
Institutions
- Chang'an University (CN)
- Air Force Engineering University (CN)
- Xi'an Medical University (CN)
- Xijing Hospital (CN)
- China Astronaut Research and Training Center (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-10-08
- DOI
- https://doi.org/10.1186/s12964-025-02420-8
- Citations
- 3
- Primary Topic
- High Altitude and Hypoxia
- Type
- article
- Field-Weighted Citation Impact
- 5.45