CD8 T cell exhaustion-associated LncRNA signature reveals novel molecular subtypes and immune targets in hepatocellular carcinoma

Our study not only elucidates the role of CD8Tex cells in HCC but also proposes a novel molecular classification of the disease. This classification holds promise for guiding clinical immunotherapy and precision treatments tailored to different molecular subtypes of HCC, as identified through drug sensitivity analysis. This work provides a foundational framework for advancing clinical strategies in HCC treatment and the development of targeted therapies.