Histological Parameters to Assess The Impact of Topical Application of Rosemary Cream on Chemically Induced Oral Ulcer (Experimental Study)

Natural herbal compounds are increasingly being used in dentistry to treat one of the most common oral disorders. An oral ulcer is a painful sore that can arise anywhere inside the oral cavity due to various circumstances. In this study twenty-seven Albino Wistar male rats were used and exposed to chemical buccal ulcers, then were categorized into a control (left side) and an experimental side (right side) that was specifically treated with varying concentrations of rosemary cream. The animals were sacrificed, the specimens were collected, and they were assessed to investigate the effect of rosemary cream on buccal ulcers by investigation of histological characteristics. A wounded area presents early signs of healing on a histological level. Statistically, it records a highly significant difference in inflammatory cell intensity and angiogenesis at varying studied periods of wounding, and it shows increased mean values of the experimental groups treated with rosemary cream independent of concentrations compared to control sides. The current study revealed that rosemary cream promotes wound healing by modulating the inflammatory response and triggering angiogenesis.