IRF6 C-terminal phosphorylation links inflammation and cell–cell adhesion in oral keratinocytes: implications for oral lichen planus
These findings suggest that post-translational modification of IRF6 is a key regulator of immune homeostasis in the oral epithelium, priming epithelial cells to initiate an immune response upon loss of epithelial integrity and bacterial adhesion.
Authors
- Mónica Tatiana Parada-Sánchez (ORCID: https://orcid.org/0000-0001-6516-1540)
- Yuliana Andrea Osorio‐Osorno (ORCID: https://orcid.org/0000-0001-6036-0479)
- Liza L. Cox (ORCID: https://orcid.org/0000-0002-0703-7258)
- Timothy C. Cox (ORCID: https://orcid.org/0000-0001-8015-5528)
Institutions
- Universidad de Antioquia (CO)
- University of Missouri–Kansas City (US)
Publication Details
- Journal
- BMC Immunology
- Published
- 2025-10-08
- DOI
- https://doi.org/10.1186/s12865-025-00757-w
- Primary Topic
- Oral Health Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00