Novel tetrameric bispecific KK-LC-1×CD16A-armed memory-like NK cells enhance antitumor efficacy in gastric cancer
KK-LC-1×CD16A-armed CIML NK cells demonstrate significant clinical potential as a multifunctional therapeutic platform, effectively overcoming both tumor infiltration limitations and functional suppression in conventional NK cell therapies. This approach provides valuable insights for optimizing the therapeutic efficacy of CIML NK cell therapy.
Authors
- Baorui Liu (ORCID: https://orcid.org/0000-0002-2539-7732)
- Tianran Chen (ORCID: https://orcid.org/0000-0001-6828-0852)
- Manman Tian
- Jie Shen (ORCID: https://orcid.org/0000-0003-3157-4640)
- Jingyi Guo (ORCID: https://orcid.org/0000-0003-0215-2895)
- Siwen Wu (ORCID: https://orcid.org/0000-0003-2393-4650)
- Rutian Li (ORCID: https://orcid.org/0000-0003-4800-6156)
- Wenxiu Chen (ORCID: https://orcid.org/0000-0001-5673-1783)
- Lanqi Cen
- Yuxiang Li (ORCID: https://orcid.org/0000-0002-9547-1838)
- Ying Wang (ORCID: https://orcid.org/0000-0003-4524-1812)
- Qin Liu (ORCID: https://orcid.org/0000-0001-9839-8480)
- Lu Zou (ORCID: https://orcid.org/0009-0008-2354-6002)
- Jie Shao (ORCID: https://orcid.org/0000-0003-1222-0505)
- Mengzhu Li
Institutions
- Nanjing Drum Tower Hospital (CN)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1136/jitc-2025-012504
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Government of Jiangsu Province
- Nanjing University
- Nanjing Drum Tower Hospital