Neural stem cell-delivered oncolytic virus via intracerebroventricular administration enhances glioblastoma therapy and immune modulation
NSCs serve as efficient OV carriers, enhancing tumor targeting, suppressing GBM progression, and modulating the immune landscape. The combination with Paquinimod amplifies therapeutic benefits, offering a promising strategy for improving GBM treatment outcomes.
Authors
- Bin Liu (ORCID: https://orcid.org/0000-0002-5051-8006)
- Houshi Xu (ORCID: https://orcid.org/0000-0002-2878-0913)
- Kang-jian Zhang
- Huihui Chai (ORCID: https://orcid.org/0000-0001-7292-8586)
- Shan Jiang (ORCID: https://orcid.org/0000-0003-1015-126X)
- Maoyuan Sun (ORCID: https://orcid.org/0009-0003-1247-182X)
- Xicai Sun (ORCID: https://orcid.org/0000-0003-1423-0942)
- Tingting Zhang (ORCID: https://orcid.org/0000-0003-1944-0738)
- Jiawen Chen (ORCID: https://orcid.org/0000-0001-7101-3034)
- Yue Wang (ORCID: https://orcid.org/0000-0003-0802-1140)
- Xiaoming Wang (ORCID: https://orcid.org/0000-0003-0679-9768)
- Liangfu Zhou (ORCID: https://orcid.org/0000-0001-6808-7120)
- Zhifeng Shi (ORCID: https://orcid.org/0000-0003-1719-0456)
- Ruize Zhu
Institutions
- Zhejiang Sci-Tech University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- Shanghai CASB Biotechnology (China) (CN)
- National Institute of Neurological Disorders and Stroke (US)
- Beijing Institute of Neurosurgery (CN)
- Shanghai Institute of Microsystem and Information Technology (CN)
- Shanghai Clinical Research Center (CN)
- Huashan Hospital (CN)
- Shanghai Center for Brain Science and Brain-Inspired Technology (CN)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1136/jitc-2025-012934
- Citations
- 2
- Primary Topic
- Virus-based gene therapy research
- Type
- article
- Field-Weighted Citation Impact
- 3.63