Central venous catheter infections: building a causal model with expert domain knowledge to inform future clinical trials
Our causal DAG provides a structured representation of CLABSI risk factors, which may support the design of clinical trials examining interventions to reduce CVC-related infections. By clarifying causal mechanisms, the DAG can enhance the specificity of endpoints and improve the rigor of prevention strategies.
Authors
- Karina Charles (ORCID: https://orcid.org/0000-0002-8279-5155)
- Tom Snelling (ORCID: https://orcid.org/0000-0003-4670-0638)
- Jessica Schults (ORCID: https://orcid.org/0000-0002-5406-9519)
- Yue Wu (ORCID: https://orcid.org/0000-0002-3121-5405)
- Claire M. Rickard (ORCID: https://orcid.org/0000-0002-6341-7415)
- Charlie McLeod (ORCID: https://orcid.org/0000-0002-3197-7493)
- Daner Ball (ORCID: https://orcid.org/0000-0002-9438-5428)
- Gladymar Pérez Chacón (ORCID: https://orcid.org/0000-0001-6629-1603)
- Hideto Yasuda (ORCID: https://orcid.org/0000-0003-3153-1595)
- Julie Marsh (ORCID: https://orcid.org/0000-0001-8984-6907)
Institutions
- Griffith University (AU)
- The University of Sydney (AU)
- Queensland Health (AU)
- Jichi Medical University (JP)
- The University of Queensland (AU)
- The Kids Research Institute Australia (AU)
- The University of Western Australia (AU)
- Children's Hospital at Westmead (AU)
- Charles Darwin University (AU)
- Menzies School of Health Research (AU)
- Metro South Health (AU)
- Keio University Hospital (JP)
- Sydney Children’s Hospitals Network (AU)
- Jichi Medical University Saitama Medical Center (JP)
Publication Details
- Journal
- Antimicrobial Resistance and Infection Control
- Published
- 2025-10-08
- DOI
- https://doi.org/10.1186/s13756-025-01630-6
- Citations
- 1
- Primary Topic
- Central Venous Catheters and Hemodialysis
- Type
- article
- Field-Weighted Citation Impact
- 2.52
Funders
- National Health and Medical Research Council