Fungal microbiota signatures anticipate neoadjuvant immunochemotherapy outcomes in esophageal cancer
Baseline gut mycobiome signatures predict NICT response in ESCC with high accuracy. Experimental validation confirms functional causality, enabling precision medicine approaches for patient stratification and identifying therapeutic targets.
Authors
- Shijie Mai (ORCID: https://orcid.org/0000-0001-6798-142X)
- Xinying Wang (ORCID: https://orcid.org/0000-0003-2956-0856)
- Gautam Sethi (ORCID: https://orcid.org/0000-0002-8677-8475)
- Lele Wu (ORCID: https://orcid.org/0000-0002-3596-0293)
- Yongjian Zhou (ORCID: https://orcid.org/0000-0003-1721-7639)
- Le Liu (ORCID: https://orcid.org/0000-0002-9270-9951)
- Yanyan Luo (ORCID: https://orcid.org/0000-0003-0703-5946)
- Jimin Han (ORCID: https://orcid.org/0000-0003-3836-6692)
- Zeheng Ma
- Di Lu (ORCID: https://orcid.org/0000-0003-1040-7763)
- Liping Liang (ORCID: https://orcid.org/0009-0001-5638-5881)
- Ruijun Cai (ORCID: https://orcid.org/0009-0009-7036-3126)
Institutions
- National University of Singapore (SG)
- Nanfang Hospital (CN)
- Guangzhou First People's Hospital (CN)
- Zhujiang Hospital (CN)
- Henan Provincial People's Hospital (CN)
- Southern Medical University Shenzhen Hospital (CN)
- Southern Medical University (CN)
- South China University of Technology (CN)
- Guangzhou Medical University (CN)
- Tsinghua University (CN)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1136/jitc-2025-011508
- Citations
- 2
- Primary Topic
- Esophageal Cancer Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.01
Funders
- National Natural Science Foundation of China
- Basic and Applied Basic Research Foundation of Guangdong Province