A multi-omics Mendelian randomization study reveals PAM as a potential therapeutic target for type 2 diabetes
This study positions PAM as a clinically relevant therapeutic target for T2D, offering new opportunities for β-cell preservation therapies and diagnostic biomarker development.
Authors
- Yunqiang Liu (ORCID: https://orcid.org/0000-0001-7691-7630)
- Qiuyue Guan
- Ming Yi (ORCID: https://orcid.org/0000-0001-7534-3049)
- Yin Liu
- Zhiguang Su (ORCID: https://orcid.org/0000-0001-8635-9310)
- Xingrong Feng (ORCID: https://orcid.org/0009-0005-8961-8337)
Institutions
- NSF NCAR High Altitude Observatory (US)
- University of Electronic Science and Technology of China (CN)
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- State Key Laboratory of Biotherapy
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-10-08
- DOI
- https://doi.org/10.1186/s12967-025-07086-x
- Citations
- 2
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Natural Science Foundation of China
- Sichuan University
- West China Hospital, Sichuan University