Optimizing Markers for Chronic Lymphocytic Leukemia Diagnosis by Flow Cytometry: Results From the Nationwide Thai Lymphoma Study Group
Expression of CD5, CD19, and CD200 by flow cytometry demonstrated a highly sensitive and accurate diagnostic utility for CLL. Adding both CD31 and CD11c to the predictive model further improved diagnostic specificity, reaching as high as 100%. The identification of relapse-associated markers provides valuable insights for personalized treatment strategies.
Authors
- Suporn Chuncharunee (ORCID: https://orcid.org/0000-0002-0028-9620)
- Lalita Norasetthada (ORCID: https://orcid.org/0000-0002-2223-5711)
- Chantiya Chanswangphuwana (ORCID: https://orcid.org/0000-0002-5258-2140)
- Ornnicha Sathitakorn (ORCID: https://orcid.org/0000-0002-2347-6074)
- Nisa Makruasi (ORCID: https://orcid.org/0009-0000-4003-1061)
- Sirorat Kobbuaklee (ORCID: https://orcid.org/0000-0003-2252-7586)
- Udomsak Bunworasate (ORCID: https://orcid.org/0000-0002-8887-4292)
- Pisa Phiphitaporn
- Kitsada Wudhikarn (ORCID: https://orcid.org/0000-0001-9528-8681)
- Tanin Intragumtornchai (ORCID: https://orcid.org/0000-0003-2687-3611)
- Jakrawadee Julamanee (ORCID: https://orcid.org/0000-0002-6526-9479)
- Peerapon Wong (ORCID: https://orcid.org/0000-0002-1754-5774)
- Chantana Polprasert (ORCID: https://orcid.org/0000-0001-6949-4449)
- Thanawat Rattanathammethee (ORCID: https://orcid.org/0000-0003-2731-4889)
- Anothai Chintabanyat
- Chayapa Thookhamme (ORCID: https://orcid.org/0009-0003-2852-4172)
- Archrob Khuhapinant
Institutions
- Prince of Songkla University (TH)
- Siriraj Hospital (TH)
- Chulalongkorn University (TH)
- Khon Kaen University (TH)
- Mahidol University (TH)
- Navamindradhiraj University (TH)
- King Chulalongkorn Memorial Hospital (TH)
- Chulabhorn Hospital (TH)
- Ramathibodi Hospital (TH)
- Chiang Mai University (TH)
- Naresuan University (TH)
- Srinakharinwirot University (TH)
Publication Details
- Journal
- Journal of Clinical Laboratory Analysis
- Published
- 2025-10-08
- DOI
- https://doi.org/10.1002/jcla.70116
- Primary Topic
- Chronic Lymphocytic Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Thailand Center of Excellence for Life Sciences
- Chulalongkorn University
- Faculty of Medicine, Chulalongkorn University
- Janssen Pharmaceuticals