Sex differences in vulnerability to tau pathology: Impact on cognitive decline
A<sup>+</sup>T<sup>-</sup> males showed faster cognitive decline compared to A<sup>+</sup>T<sup>-</sup> females. A<sup>+</sup>T<sup>+</sup> females showed faster cognitive decline compared to A<sup>+</sup>T<sup>+</sup> males. Tau status significantly mediated the relationship between amyloid status and cognitive decline. Sex marginally moderated the mediating relationship between amyloid, tau, and cognitive decline. The findings point to sex differences in the impact of tau pathology on cognition.
Authors
- Yashar Zeighami (ORCID: https://orcid.org/0000-0002-0583-5811)
- Cécilia Tremblay (ORCID: https://orcid.org/0000-0001-8460-7421)
- Mahsa Dadar (ORCID: https://orcid.org/0000-0003-4008-2672)
Institutions
- Douglas Mental Health University Institute (CA)
- McGill University (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1002/alz.70634
- Citations
- 3
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 4.41
Funders
- National Institutes of Health
- Canadian Institutes of Health Research
- Natural Sciences and Engineering Research Council of Canada
- National Institute on Aging