Cornuside mitigates acute lung injury through suppression of NLRP3 inflammasome-mediated pyroptosis and activation of the Keap1-Nrf2 antioxidant response
These findings demonstrate that CNS protects against LPS-induced ALI by concurrently suppressing NLRP3 inflammasome-mediated pyroptosis and enhancing Keap1-Nrf2 antioxidant signaling. This dual mechanism highlights CNS as a promising natural therapeutic candidate for ALI and related oxidative stress-driven lung diseases.
Authors
- Ai Liya
- Saiyin Chaoketu (ORCID: https://orcid.org/0000-0002-5371-0159)
- Feng Wang
- Wei Yan (ORCID: https://orcid.org/0009-0002-4403-1098)
- Tong Luo (ORCID: https://orcid.org/0000-0002-1592-7867)
Institutions
- Beijing University of Chinese Medicine (CN)
- China Electronic Information Industry Development (CN)
- Inner Mongolia International Mongolian Hospital (CN)
- Inner Mongolia Medical University (CN)
- Wuhan Sports University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-10-08
- DOI
- https://doi.org/10.3389/fphar.2025.1682523
- Citations
- 1
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Hubei Provincial Department of Education
- National Natural Science Foundation of China