Switchable pathways of multicomponent heterocyclizations of 5-amino-1,2,4-triazoles with salicylaldehydes and pyruvic acid
Switchable multicomponent reactions involving 3-substituted-5-amino-1,2,4-triazoles, pyruvic acid, and salicylaldehydes were studied under different conditions. Upon conventional heating, benzotriazolooxadiazocine-5-carboxylic acids were formed in the three-component reactions as single reaction products. Upon ultrasonic activation or mechanical stirring at room temperature, the multicomponent reaction of the same starting materials led to the formation of only tetrahydrotriazolopyrimidine derivatives.
Authors
- Валентин А. Чебанов (ORCID: https://orcid.org/0000-0001-7564-778X)
- Svitlana V. Shishkina (ORCID: https://orcid.org/0000-0002-3946-1061)
- Oleksandr V. Buravov (ORCID: https://orcid.org/0009-0008-8433-5524)
- Yana I. Sakhno (ORCID: https://orcid.org/0000-0003-0561-635X)
- Kostyantyn Yu Yurkov
- Anastasia Yu Andryushchenko
Institutions
- State Scientific Institution “Institute for Single Crystals” of National Academy of Sciences of Ukraine (UA)
- Enamine (Ukraine) (UA)
- V. N. Karazin Kharkiv National University (UA)
Publication Details
- Journal
- Beilstein Journal of Organic Chemistry
- Published
- 2025-10-08
- DOI
- https://doi.org/10.3762/bjoc.21.158
- Primary Topic
- Multicomponent Synthesis of Heterocycles
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation of Ukraine
- National Research Foundation