Single-cell sequencing reveals distinct peripheral immune responses in anti-MDA5 antibody positive dermatomyositis with rapidly progressive interstitial lung disease
This study demonstrates that antiviral response plays an important role in the pathogenesis of MDA5<sup>+</sup> DM with RPILD, as well as changes in downstream immune pathways, providing potential therapeutic targets for future treatment.
Authors
- Enqi Liu (ORCID: https://orcid.org/0000-0002-2092-3158)
- Zhenke Wen (ORCID: https://orcid.org/0000-0003-0542-0349)
- Lei Shen (ORCID: https://orcid.org/0000-0003-0671-0567)
- R. J. Hu (ORCID: https://orcid.org/0009-0002-5361-3604)
- Hui Zheng (ORCID: https://orcid.org/0000-0003-3085-4560)
- Chenghua Weng (ORCID: https://orcid.org/0000-0001-7253-7745)
- Yiting Ji (ORCID: https://orcid.org/0000-0001-5353-846X)
- Zhichun Liu (ORCID: https://orcid.org/0000-0001-6170-9601)
- Gang Wang (ORCID: https://orcid.org/0000-0002-8836-1593)
- Lei Zhang (ORCID: https://orcid.org/0000-0003-4105-0824)
Institutions
- Soochow University (CN)
- Suzhou Municipal Hospital (CN)
- Second Affiliated Hospital of Soochow University (CN)
- First Affiliated Hospital of Soochow University (CN)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2025-10-08
- DOI
- https://doi.org/10.1186/s13075-025-03639-z
- Citations
- 1
- Primary Topic
- Inflammatory Myopathies and Dermatomyositis
- Type
- article
- Field-Weighted Citation Impact
- 1.35