Liver-Specific Nanoparticle-Mediated Delivery and MMP-Triggered Release of Veratridine to Effectively Target Metastatic Colorectal Cancer
This study introduces a new platform utilizing nanoparticle-based site-specific delivery of a plant-based anti-metastatic molecule, veratridine, with enhanced safety and therapeutic efficacy for the treatment of metastatic CRC.
Authors
- Jessica Freeling (ORCID: https://orcid.org/0000-0002-1003-9174)
- Morgan Eikanger (ORCID: https://orcid.org/0000-0002-6435-6175)
- Khosrow Rezvani (ORCID: https://orcid.org/0000-0003-1963-2211)
- Grigoriy Sereda (ORCID: https://orcid.org/0000-0002-1121-8211)
- John L. Slunecka (ORCID: https://orcid.org/0000-0001-6462-1146)
- Mahadi Hasan (ORCID: https://orcid.org/0009-0006-8767-0905)
- Sanam Sane
- Krishantha S. K. Wijewardhane (ORCID: https://orcid.org/0000-0002-1348-8274)
Institutions
- University of South Dakota (US)
Publication Details
- Journal
- Cancers
- Published
- 2025-10-08
- DOI
- https://doi.org/10.3390/cancers17193253
- Citations
- 2
- Primary Topic
- Peptidase Inhibition and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 2.09
Funders
- University of Utah
- University of South Dakota
- Colorectal Cancer Alliance
- National Institutes of Health
- National Cancer Institute