A single oral administration of flavanols enhances short-term memory in mice along with increased brain-derived neurotrophic factor
These findings suggest that FLs enhance short-term memory via hippocampal CREB activation and BDNF upregulation. Despite low systemic absorption, the rapid effects observed may involve sensory signaling pathways, potentially triggered by the astringent properties of FLs. This study provides mechanistic insight into the cognitive benefits of dietary FLs.
Authors
- Yuki Yamato (ORCID: https://orcid.org/0000-0002-5288-9329)
- Shu Taira (ORCID: https://orcid.org/0000-0002-9243-0395)
- Vittorio Calabrese (ORCID: https://orcid.org/0000-0002-0478-985X)
- Kazunori Takano (ORCID: https://orcid.org/0000-0001-9400-8588)
- Naomi Osakabe (ORCID: https://orcid.org/0000-0001-8159-7053)
- Yoritaka Fujii (ORCID: https://orcid.org/0000-0003-1417-0484)
- Minoru Shibata
- Sota Tsuchibuchi
Institutions
- Shibaura Institute of Technology (JP)
- University of Catania (IT)
- Fukushima University (JP)
Publication Details
- Journal
- Open Medicine
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1515/med-2025-1270
- Primary Topic
- Neurogenesis and neuroplasticity mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00