Comparative <i>in vivo</i> PET imaging of silica microparticles: shape-dependent blood circulation and short-term biodistribution
Particles at the nanometric-micrometric interface hold promise by combining the drug-loading capacity of microparticles with the systemic benefits of nanoparticles. We assess the <i>in vivo</i> behaviour in mice <i>via</i> PET imaging of silica rods and spheres (∼1 μm), showing different biodistributions thus highlighting the potential for shape-dependent targeting.
Authors
- Juan Pellico (ORCID: https://orcid.org/0000-0003-2787-8641)
- Jan Grzelak (ORCID: https://orcid.org/0000-0002-8404-0389)
- Anna Roig (ORCID: https://orcid.org/0000-0001-6464-7573)
- Rafael T. M. de Rosales (ORCID: https://orcid.org/0000-0003-0431-0535)
- Martí Gich (ORCID: https://orcid.org/0000-0001-9958-0057)
Institutions
- St Thomas' Hospital (GB)
- King's College London (GB)
- Instituto de Ciencia de Materiales de Sevilla (ES)
- Institut de Ciència de Materials de Barcelona (ES)
Publication Details
- Journal
- Dalton Transactions
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5dt00412h
- Primary Topic
- Mesoporous Materials and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wellcome Trust
- Generalitat de Catalunya
- Medical Research Council
- Engineering and Physical Sciences Research Council
- Agencia Estatal de Investigación
- Centre For Medical Engineering, King’s College London