miR-320a Regulates Placenta Endothelial Function After Fetal Cardiopulmonary Bypass via the ATG7-SIRT1/FOXO1 Pathway
The observed downregulation of placental ATG7 expression subsequent to fetal CPB is intricately associated with endothelial dysfunction. Furthermore, our findings underscore the specific regulatory role of miR-320a in modulating ATG7 expression within the placenta. At the cellular level, increasing the level of miR-320a has emerged as a potential strategy for modulating endothelial function through the inhibition of ATG7 and the SIRT1/FOXO1 pathway.
Authors
- Qiuping Jiang
- Jian Zhuang (ORCID: https://orcid.org/0000-0003-0142-4238)
- Haiyun Yuan (ORCID: https://orcid.org/0000-0002-8884-4202)
- Jimei Chen (ORCID: https://orcid.org/0000-0002-3278-3842)
- Xiaokang Luo (ORCID: https://orcid.org/0000-0002-1343-4372)
- Miao Tian (ORCID: https://orcid.org/0000-0001-9086-1872)
- Chengbin Zhou
- Yun Teng
Institutions
- Key Laboratory of Guangdong Province (CN)
- South China Sea Institute Of Oceanology (CN)
- Guangdong Academy of Medical Sciences (CN)
- Guangdong Provincial People's Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Current Medical Science
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1007/s11596-025-00115-2
- Primary Topic
- Cardiovascular Issues in Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Key Research and Development Program of China