Candesartan preserves aortic structure and function in cisplatin-treated rats by upregulating SIRT1/Nrf2/HO-1 signaling and suppressing oxidative stress, TLR-4/NF-κB signaling, and necroptosis
These findings suggest that CAN protects against CIS-induced vascular injury through coordinated suppression of oxidative stress, inflammation, and necroptosis, alongside upregulation of SIRT1/Nrf2/HO-1 signaling and restoration of vascular function. CAN may represent a promising vascular-protective strategy in patients undergoing CIS chemotherapy.
Authors
- Emad H. M. Hassanein (ORCID: https://orcid.org/0000-0003-4865-2342)
- Ahmed M. Atwa (ORCID: https://orcid.org/0000-0001-8580-4179)
- Ayman M. Mahmoud (ORCID: https://orcid.org/0000-0003-0279-6500)
- Hanan S. Althagafy (ORCID: https://orcid.org/0000-0002-3161-9063)
- Sulaiman Mohammed Alnasser (ORCID: https://orcid.org/0000-0001-8678-5029)
- Reem S. Alruhaimi (ORCID: https://orcid.org/0000-0003-3746-8582)
- Omnia A. M. Abd El‐Ghafar
Institutions
- Princess Nourah bint Abdulrahman University (SA)
- Manchester Metropolitan University (GB)
- Qassim University (SA)
- Al-Azhar University (EG)
- Nahda University (EG)
- University of Jeddah (SA)
- Egyptian Russian University (EG)
- Assiut University (EG)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-10-08
- DOI
- https://doi.org/10.3389/fphar.2025.1678921
- Primary Topic
- Antioxidant Activity and Oxidative Stress
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Princess Nourah Bint Abdulrahman University